Astodol MR 100mg/250mg/325mg Tablet is a combination medicine that helps in relieving muscular pain. It works by blocking the release of certain chemical messengers that cause pain, inflammation, and fever. It also relieves muscle stiffness or spasm and improves muscle movement. Astodol MR 100mg/250mg/325mg Tablet can be taken with or without food. The dose and duration will depend on the severity of your condition. You should keep taking the medicine even if you feel better until the doctor says it is alright to stop using it. Using this medicine may cause common side effects such as sleepiness, nausea, vomiting, diarrhea, stomach pain, dryness in the mouth, and loss of appetite. If any of these side effects do not resolve with time or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the side effects. In general, you should try to use the smallest amount necessary to control your symptoms. Before using the medicine, you should tell your doctor if you have any other medical conditions or disorders. To make sure it is safe, you should let your doctor know all the other medicines you are taking. Also, tell your doctor if you have any problems with the liver or kidneys. You should avoid the consumption of alcohol while on treatment with this medicine. Pregnant and breastfeeding women should consult their doctors first before using the medicine.