Benfo Plus tablet is a unique combination of Benfothiamine with Methylcobalamin, Pyridoxine and Folic acid. It is an essential nutrient for development of the nervous system. Treatment with Benfotiamine leads to increased intracellular thiamine diphosphate levels,a cofactor of transketolase. This enzyme directs advanced glycation and lipoxidation end products (AGE's, ALE's) substrates to the pentose phosphate pathway, thus reducing tissue free radicals (AGEs). Methylcobalamin is needed for the healthy development and sustenance of our circulatory, immune and nervous systems. Methylcobalamin offers nerve cell support in the brain, and contributes to stronger overall central nervous system function. Directions for use: In alcoholic neuropathy, diabetic neuropathy the recommended dose is 100 mg 4 times a day. Use under medical supervision.