Debura 300 mg/500 mg Tablet contains two different types of painkiller. They work in different ways to reduce pain and fever. The combination is used to treat many conditions such as headache, period pain, toothache, colds and mild arthritis. These are also common ingredients in many cold and flu remedies. Your doctor will advise how much Debura 300 mg/500 mg Tablet you need to take, and you should also read the leaflet that comes with it to get the most benefit. This combined medication is best taken with food to reduce side effects. In general, you should try to use the smallest amount necessary to control your symptoms, for the shortest possible time. However, for some conditions, such as arthritis, it may take up to two weeks to get the full benefit and you may need to take it for a long time. You should take this medicine regularly while you do need it; try not to miss doses as it will become less effective. Medicines used to treat pain are usually best taken at the first sign of pain. It very rarely causes side effects if it is used correctly but this combined medicine may cause heartburn, stomach pain, nausea, and indigestion. You can reduce the chances of getting any side effects by using the minimum dose you need. If you take more than you should, talk to a doctor straight away, even if you feel well because too much paracetamol can cause liver damage. This medicine is widely prescribed and considered safe but is not suitable for everybody. Before you take it, you should tell your doctor if you have kidney problems, asthma, blood disorders, or drink a lot of alcohol. Also, tell your doctor what other medicines you are taking to make sure you are safe. It is best to avoid drinking alcohol while using this medicine.