Defen Plus Gel is a combination medicine used in the treatment of pain due to muscle spasm. It improves the movement of muscles and provides relief from pain and discomfort associated with muscle spasms. Defen Plus Gel is only meant for external use and should be used strictly as advised by your doctor. Rub a thin layer of the medicine into the affected areas with clean and dry hands. Avoid getting in contact with your eyes, nose, or mouth, and avoid applying it on wounded or damaged skin. In case of accidental contact with these areas, you should rinse them with plenty of cold water. The medicine is generally safe with little or no side effects. However, it may cause burning or stinging sensation, irritation, itching, and redness at the site of application in some people. Usually, the side effects will slowly go away as your body gets used to it. If they get worse or do not go away, you should let your doctor know. Although medicines used on the skin are not normally affected by other medicines you should let your doctor know if you are taking any other medicine to be safe. You should also let your doctor know if you have any medical conditions or disorders to make sure it is safe. Ask your doctor for advice if you are pregnant or breastfeeding.