Depten 50 mg/20 mg Tablet is a medicine used to treat hypertension (high blood pressure). This combination medicine controls blood pressure when a single medication is not effective. By lowering the blood pressure, it helps in preventing future heart attack and stroke. You can take Depten 50 mg/20 mg Tablet at any time of day, on empty stomach, but it is best to take it at the same time each day. Keep taking it for as long as advised by your doctor. Even if you feel well, do not stop this medicine on your own because high blood pressure often has no symptoms. If you stop taking it, your condition may get worse. Keeping active with regular exercise, reducing your weight and eating a healthy diet will also help control your blood pressure. Follow your doctor’s advice while taking this medicine. It may cause side effects like fatigue, ankle swelling, headache, slow heart rate, and nausea. It may also cause dizziness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. To reduce the swelling, raise your legs while sitting down. You may be asked for regular monitoring of blood pressure, kidney function, and electrolytes level while on the treatment. Before taking it, let your doctor know if you have any liver or kidney problems. Pregnant or breastfeeding women should also consult their doctor for advice before taking this medicine. You also need to tell your doctor what other medicines you are taking especially those used to treat high blood pressure or heart conditions.