Materna Depot 3.75mg Injection is used in the treatment of infertility in women. It is also helpful in the treatment of male hypogonadism (delayed puberty, and low sperm count). It works by releasing the eggs from the ovary in women and by increasing the testosterone level in men. Materna Depot 3.75mg Injection is given as an injection under the supervision of a doctor. Your doctor will decide the right time to take the injection, so always follow your doctor's advice. The dose and how often you take it depends on what you are taking it for. You should take this medicine for as long as it is prescribed for you. The most common side effects of this medicine include injection site pain, headache, fatigue, and depression. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Male might notice acne, or sweating and deepening of the voice. If you experience dizziness, faint, abdominal pain, and vomiting after getting the injection, inform your doctor immediately. Before taking this medicine, tell your doctor if you have ever had heart disease, or had an ovarian cyst, or had thyroid gland disorder. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Tell your doctor if you are pregnant or breastfeeding. You should avoid alcohol or have to follow doctor advice related to diet while taking this medicine.