Nicoclin 4% Gel is a medicine used for treatment of acne and and other inflammatory skin disorders caused by deficiency of vitamin B3 in the body. It helps in reducing the inflammation and redness in the skin. Nicoclin 4% Gel may be used alone or with other acne treatments. You should use it as per your doctor's advice. The leaflet that comes with the product will also give instructions which you should read to get the most out of this medicine. You should normally wash and dry the affected area before applying a thin layer of the medicine. You should not apply it to damaged or broken skin and avoid contact with your mouth, eyes, and nose. Nicoclin 4% Gel has some common side effects including application site reactions such as burning, irritation, itching, and redness, as well as dry skin. They are not usually serious but if they bother you or do not go away with time, tell your doctor. You should tell your doctor if you have any other skin conditions or if you are taking any other medicines, especially those applied to the skin. It may not be suitable if you have very sensitive skin.