Ningigo S 0.25mg/25mg Tablet is a prescription medicine used to treat depression. It is a combination medicine which calms the brain by decreasing the abnormal and excessive activity of the nerve cells. It also increases the levels of some chemical messengers in the brain and improves mood. Ningigo S 0.25mg/25mg Tablet is taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain consistent levels of medicine in the body. Take this medicine in the dose and duration advised by your doctor as it has habit-forming potential. If you miss a dose of this medicine, take it as soon as you remember. Finish the full course of treatment even if you feel better. It is important not to stop taking this medicine suddenly as this may cause nausea, stomach upset, flu-like withdrawal symptoms, sleep disturbance and anxiety. Some common side effects of this medicine include nausea, vomiting, diarrhea, confusion, memory impairment, and low sexual desire. It may also cause dizziness and sleepiness. So, do not drive or do anything that requires mental focus until you know how this medicine affects you. It may cause weight gain or weight loss depending upon person to person. To prevent weight gain, you can eat a healthy balanced diet, avoid snacking with high-calorie food and exercise regularly. On the other hand, weight loss can be managed by consulting a dietitian who can help you increase the food portions. It is important to inform your doctor if you develop any unusual changes in mood as it may cause suicidal thoughts. Take caution while taking medicine if you are suffering from liver disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.