Retisphere Gel is a prescription medicine having combination of medicines that are used to treat acne. It removes the dead layer of the skin which is present on the top. It stops the growth of bacteria. Retisphere Gel should be used in the dose and duration as advised by your doctor. It is for external use only. Wash your hands before using this medicine. Apply only on the affected areas of the skin. It is advised to check the label for directions before use. The most common side effects include skin irritation, itchiness and burning, and sensation at the application site. If this side effect persist for a longer duration, inform your doctor. In case by accident, this medicine goes into your eyes, ears, nose or mouth, immediately rinse it with water. Inform your doctor if you notice darkening or discoloration, or severe burning sensation at the treated skin. Inform your doctor if you have known allergies from this medicine. If you are pregnant or breastfeeding suffering from any other condition, please inform your doctor.