Topibrite H3 3% Cream is used in the treatment of melasma. It is a skin-lightening medicine that lightens the darkened skin patches and spots(hyperpigmentation). It reduces the amount of skin-darkening pigment called melanin in the skin. It helps in reversible depigmentation of the skin. Topibrite H3 3% Cream is for external use only. You should use it in the dose and duration as advised by your doctor. You must wash your hands thoroughly before and after applying this medicine. This medicine should be used regularly to get the most benefit from it. Do not use more than you need as some side effects may be increased. Topibrite H3 3% Cream has a few potential side effects but not everyone will get them. These may include dry skin, itching, skin burn, skin peeling, and skin redness. Serious allergic reaction to this drug is rare but let your doctor know if you’re bothered by side effects or they do not go away. Make sure you read the instructions that come with your medicine. Avoid contact with eyes. In case of accidental contact, you should rinse your eyes thoroughly with water. You can start applying Topibrite H3 3% Cream to a small portion of unbroken skin or near the pigmented area for a period of several days for checking an allergic reaction. You should discontinue it if itching, excessive inflammation, or swelling occurs. Pregnant women should consult their doctor before taking this medicine. If no improvement is seen after two months of treatment, the use of this product should be discontinued.